Eddie Brock and Venom are on the run after their recent battle with Carnage. Eddie is framed for the murder of Patrick Mulligan and must clear his name. Unbeknownst to them, a creature known as a Xenophage is tracking them. The Xenophage is a dangerous creature that is being hunted by a government agency called Imperium. Eddie and Venom must work together to defeat the Xenophage and clear Eddie's name.